Get a More Even Skin Tone And Reverse Melasma (the mask of pregnancy) And Undesired Skin Discoloration

Even Skin Tone – How To Get Rid of Hyperpigmentation?

even skin tone

Biological skin cream yields a more even or refined skin tone when applied to Melasma (the mask of pregnancy) and other undesired skin pigmentations.

Is your natural beauty hidden behind a mask of dark, irregular patches on the upper cheek, the nose, lips, upperlip, and/or your forehead? Would you prefer lighter/brighter skin?

BIO SKIN REJUVENATION is a new biological skin care product that embodies (a) natural enzymes that dissolve damaged tissues & excess melanin deposits acting in concert with (b) skin renewal activators that speed keratinocyte turnover, while (c) melanogenesis inhibitors reduce the biosynthesis of melanin, thereby hastening the resolution of melasma and hyperpigmentation disorders by reducing the time it takes for the whole process of healthy skin renewal.

While melasma literally means dark skin, and it is best known as the “mask of pregnancy”, you don´t have to be pregnant (or even a woman!) to develop melasma. And if you think you´re silently suffering alone, think again. An estimated six million women throughout the U.S. are currently affected by this distressing, albeit cosmetic concern.

Melasma is a tan or dark facial skin discoloration or hyperpigmentation. Although it can affect anyone, melasma is particularly common in women, especially pregnant women and those who are taking oral contraceptives or hormone replacement therapy (HRT) medications. However, this condition develops spontaneously in some women who are neither pregnant, taking oral contraceptives, nor HRT medications. It is also prevalent in men and women of Native American descent (on the forearms) and in men and women of German/Russian Jewish descent (on the face).

The cheeks, the upper lip, the chin, and the forehead are the most common locations, but it can occasionally occur in other sun-exposed locations. Chloasma is a synonymous term sometimes used to describe the occurrence of melasma during pregnancy (also known as the mask of pregnancy). Chloasma is derived from the Greek word chloazein, meaning “to be green.” Melas, also Greek, means “black.”

Race: Persons of any race can be affected. However, it is much more common in constitutionally darker skin types than in lighter skin types, and it may be more common in light brown skin types, especially Hispanics and Asians, from areas of the world with intense sun exposure.

Sex: Melasma is much more common in women than in men. Women are affected in 90% of cases. When men are affected, the clinical and histologic picture is identical.

Age: Melasma is rare before puberty and most commonly occurs in women during their reproductive years.

The color of human skin is differentiated by the nature and quantity of the natural pigment, melanin, present in the epidermal layers of the skin.

Cutaneous pigmentation is the outcome of two events: the synthesis of melanin by melanocytes (MC) and the donation of melanin in melanosomes (organelles within the cells) to surrounding keratinocyte cells. The rate of melanin synthesis is determined by intracellular enzymes, the best characterized of which are tyrosinase, and the two tyrosinase-related proteins (TRP)-1 and TRP-2 or DOPAchrome tautomerase (DT).

The formation of melanin from amino acid tyrosine involves several biogenetic steps mediated initially by the enzyme tyrosinase. Tyrosine is first oxidized by tyrosinase to dihydroxyphenylalanine (I-dopa), then to dopaquinone. Dopaquinone is then converted into eumelanin (black, white, and Asian skin types; skin color is dependent on the quantity of eumelanin in skin), or phaeomelanin (red-haired skin types). This conversion proceeds through the intermediate formation of leucodopachrome and dopachrome (eumelanin), or cysteinyldopa (phaeomelanin).

Causes of Melasma

Melasma is thought to be the result of stimulation of melanocytes or pigment-producing cells by the female sex hormones estrogen and progesterone to produce more melanin pigments when the skin is exposed to sun. Women with a light brown skin type who are living in regions with intense sun exposure are particularly susceptible to developing this condition.

A direct relationship with female hormonal activity appears to cause melanocytes or the pigment-producing cells to produce and deposit excess pigments, because it occurs with pregnancy and with the use of oral contraceptive pills. Other factors implicated in melasma are photosensitizing medications, mild ovarian or thyroid dysfunction, and certain cosmetics.

Genetic predisposition is also a major factor in determining whether someone will develop melasma. It is much more common in women than in men. Persons with light brown skin types from regions of the world with intense sun exposure are much more prone to the development of melasma. More than 30% of patients have a family history of melasma. Identical twins have been reported to develop melasma, while other siblings under similar conditions did not.

Another major factor is exposure to sunlight. Ultraviolet radiation can cause peroxidation of lipids in cellular membranes, leading to generation of free radicals, which could stimulate melanocytes to produce excess melanin. Sunscreens that primarily block UV-B radiation (290-320 nm) are unsatisfactory because longer wavelengths (UV-A and visible radiation, 320-700 nm) also stimulate melanocytes to produce melanin.

Hormonal influences play a role in some individuals. The mask of pregnancy is well known to obstetric patients. The exact mechanism by which pregnancy affects melasma is unknown. Estrogen, progesterone, and melanocyte-stimulating hormone (MSH) levels are normally increased during the third trimester of pregnancy. However, nulliparous patients with melasma have no increased levels of estrogen or MSH. In addition, the occurrence of melasma with estrogen- and progesterone-containing oral contraceptive pills and diethylstilbestrol treatment for prostate cancer has been reported. The observation that postmenopausal woman who are given progesterone develop melasma, while those who are given only estrogen do not, implicates progesterone as playing a critical role in the development of melasma.

The discoloration usually disappears spontaneously over a period of several months after giving birth or stopping the oral contraceptives or hormone replacement therapy.

The incidence of melasma also increases in people with thyroid disease. It is thought that the overproduction of melanocyte-stimulating hormone (MSH) brought on by stress can cause outbreaks of this condition. Other rare causes of melasma include allergic reaction to medications and cosmetics.

One study found a 4-fold increase in thyroid disease in patients with melasma when compared with matched controls. A case report of 2 women who developed melasma after sudden and profound emotional stress implicated the release of MSH by the hypothalamus as a cause. Exactly which hormones and what mechanisms are involved in the development of melasma are yet to be determined. Genetic and hormonal influences in combination with ultraviolet radiation are the 2 most important causes of melasma, yet phototoxic and photoallergic medications and certain cosmetics have been reported to cause melasma in rare instances.

The most important factor in the development of melasma is exposure to sunlight. Without the strict avoidance of sunlight, potentially successful treatments for melasma are doomed to fail.

Hyperpigmentation is an area of the skin where there is an overabundance of melanin relative to the surrounding cutaneous tissue. This can be the result of either an abnormally high concentration of melanocytes producing the melanin, or hyperactive melanocytes. Melanin is increased in the epidermis, in the dermis, or (most commonly) in both locations. Epidermal melanin is found in keratinocytes in the basal and suprabasal area. In most cases, the number of melanocytes is not increased, yet the melanocytes that are present are larger, more dendritic, and more active. Dermal melanin is found in the superficial and mid dermis within macrophages, which often congregate around small, dilated vessels. Inflammation is sparse or absent.

Excess melanin can be visually localized to the epidermis or the dermis by use of a Wood lamp (wavelength, 340-400 nm).

Reduction of Hyperpigmentation

Melasma can be difficult to treat. The pigment of melasma develops gradually, and resolution is also gradual. Resistant cases or recurrences occur often and are certain if strict avoidance of sunlight is not rigidly heeded. All wavelengths of sunlight, including the visible spectrum, are capable of inducing melasma.

The cosmetic treatment of skin to produce a visible even-tone has been practiced since ancient times. The use of plant-derived extracts and salves to whiten or brighten dark colored skin has been very popular among Asian, African, and South American cultures. The even toning of age-related dark spots, skin pigmentation, freckles, and other skin pigmentation disorders with skin lightening products is gaining popularity among people of light-colored skin as well.

To date, the best-known active substance for de-pigmentation is hydroquinone, a bleaching agent which has the status of a FDA approved OTC drug active ingredient for skin whitening compositions. Kojic acid and arbutin, which are chemically related to hydroquinone, are also commonly used. If applied over long periods of time, hydroquinone can have serious side effects, which has led to its being permitted only in limited concentrations in some countries, and to its being completely forbidden for applications in cosmetic products in other countries (The chemical is under new scrutinity in the US and may soon be forbidden by the FDA).

Furthermore, hydroquinone leads to permanent de-pigmentation, and thus to increased photosensitivity of the skin when exposed to UV light. Better-tolerated skin lightening substances currently being used are of natural origin, e.g., arbutin (from the leaves of the common bearberry, Uva ursi), liquorice extract (from liquorice root), ascorbic acid (vitamin C from citrus fruits) and their derivatives, as well as kojic acid (from carbohydrate solutions under the effect of certain bacteria). These substances, which are highly soluble in water, act on the tyrosinase as competitive inhibitors; however, they are unstable in some formulations, and have the disadvantage that only very small quantities penetrate the deeper skin layers and reach the melanocytes in the basal membrane. A further disadvantage of these substances is their low level of efficacy, which necessitates their being used in high concentrations. Compared to the quantity of hydroquinone used, 17 times as much ascorbic acid and over 100 times as much arbutin is required to achieve a similar effect.

Topical applications of ascorbic acid and its esters are also claimed to have skin-lightening property. Several botanical-based ingredients with claims such as “helps reduce the appearance of minor skin discoloration”, “helps brighten skin and even-out skin tone”, “helps reduce the appearance of dark spots, age-related spots, and freckles”, and modifications of the above claims are made.

Basically, the most effective strategy is to reduce the tyrosinase, for then you reduce the melanin. The most effective way to reduce the visible signs of hyperpigmentation, is to down-regulate melanin production. This is effective because areas where more melanin is being produced will show higher levels of efficacy and respond with a greater reduction in melanin.

The good news: Rumex occidentalis extract, a plant extract, has plenty of in vivo and invitro testing showing effective action as a melanin synthesis inhibitor or tyrosinase inhibitor without undesired effects.
Treatment to lighten the dark spots include:

Treatment of Melasma

The dark spots usually go away by themselves – however, this process can take a very long time. It is not unusual to have the condition persist for months or years after giving birth or stopping taking birth control pill. Lotions with high SPF (sun protection factor) of 15 or greater should be worn if you have melasma, because sunlight and ultraviolet lights stimulate the production of melanin as a result of body’s own protective response to such external stimuli.

  • Cosmetic cover-ups to hide and reduce the appearance of spots.
  • Non-prescription BIO SKIN REJUVENATION applied to clean skin twice a day. Ideal for use under makeup
  • Over-the-counter lightening cream with 2% hydroquinone
  • Prescription lightening cream with 4% hydroquinone

Treatments to hasten the fading of the discolored patches include:

  • Topical depigmenting agents, such as hydroquinone (HQ) either in over-the-counter (2%) or prescription (4%) strength. Hydroquinone works by decreasing the production and increasing the breakdown of melanosomes (melanin pigment granules) in the skin’s pigment cells (melanocytes).
  • Tretinoin, an acid that increases skin cell (keratinocyte) turnover. This treatment cannot be used during pregnancy.
  • Azelaic acid (20%), thought to decrease the activity of melanocytes.
  • Facial peel with alpha hydroxyacids or chemical peels with glycolic acid.
  • Laser treatment. A Wood’s lamp test should be used to determine whether the melasma is epidermal or dermal. If the melasma is dermal, laser (or “IPL”) will acually DARKEN and worsen the appearance of the spots. Dermal melasma is generally unresponsive to most treaments, and has only been found to lighten with products containing mandelic acid.

Quick fixes with destructive modalities (eg, cryotherapy, medium-depth chemical peels, lasers) yield unpredictable results and are associated with a number of potential adverse effects, including epidermal necrosis, post inflammatory hyperpigmentation, and hypertrophic scars. The precise manner in which these modalities can be used has not been fully delineated. However, in some experienced hands, they have been anecdotally reported to be safe, effective, and produce results much quicker than topical medications. More careful study is needed before they can be recommended as a standard treatment.

In all of these treatments the effects are gradual and a strict avoidance of sunlight is required. The use of broad-spectrum sunscreens with physical blockers, such as titanium dioxide and zinc dioxide is preferred over that with only chemical blockers. This is because UV-A, UV-B and visible lights are all capable of stimulating pigment production.

The mainstay of treatment remains topical depigmenting agents. Hydroquinone (HQ) is most commonly used. It is a hydroxyphenolic chemical that inhibits tyrosinase, leading to the decreased production of melanin. Additionally, cytotoxic metabolites may cause interference with melanocyte function and viability. HQ can be applied in cream form or as an alcohol-based solution. Concentrations vary from a 2% concentration available in the United States without a prescription to a standard 4% concentration and even higher when compounded. Efficacy is directly linked to concentration, but the incidence of adverse effects also increases with concentration. All concentrations can lead to skin irritation, phototoxic reactions with secondary postinflammatory hyperpigmentation, and irreversible exogenous ochronosis (reported even with long-term use of 2% HQ). Special care must be taken not to prescribe the monobenzyl ether of HQ (Benoquin), which causes an irreversible localized and generalized vitiligolike leukoderma.

The use of tretinoin (trans-retinoic-acid) can be effective as monotherapy. However, the response to treatment is less than with HQ and can be slow, with improvement taking 6 months or longer. As such, combinations of tretinoin with HQ, with or without a topical corticosteroid, have been promoted. The retinoid is believed to work by increasing keratinocyte turnover and thus limiting the transfer of melanosomes to keratinocytes. The major adverse effect is skin irritation, especially when the more effective, higher concentrations are used. Temporary photosensitivity and paradoxical hyperpigmentation can also occur.

Azelaic acid, available as a 20% cream-based formulation, appears to be as effective as 4% HQ and superior to 2% HQ in the treatment of melasma. The mechanism of action is not fully understood. DNA synthesis is reduced, and mitochondrial cellular energy products are inhibited in melanocytes. Unlike HQ, azelaic acid seems to target only hyperactive melanocytes and thus will not lighten skin with normally functioning melanocytes. The primary adverse effect is skin irritation. No phototoxic or photoallergic reactions have been reported.

Other depigmenting agents that have been studied in the treatment of melasma are 4-N-butylresorcinol, phenolic-thioether, 4-isopropylcatechol, kojic acid, and ascorbic acid.

Regardless of the treatments used, all will fail if sunlight is not strictly avoided. Prudent measures to avoid sun exposure include hats and other forms of shade combined with the application of a broad-spectrum sunscreen at least daily. Sunscreens containing physical blockers, such as titanium dioxide and zinc oxide, are preferred over chemical blockers because of their broader protection. UV-B, UV-A, and visible light are all capable of stimulating melanogenesis. In addition, patients should be forewarned that resolution is gradual and may take many months.

Mild Exfoliation Combined With Accelerated Skin Renewal & Melanin Inhibition

In an attempt to hasten resolution, many practitioners attempt mild exfoliation with superficial chemical peels. The rational is that if melanogenesis is inhibited with bleaching agents and keratinocyte turnover is increased as a reaction to mild exfoliation, the time to resolution can be reduced. A number of studies have shown that treating melasma with superficial chemical peels and a bleaching agent is safe and effective.

An option that relies in a similar concept is embodied in our melasma and hyperpigmentation treatment product: BIO SKIN REJUVENATION.

This new option combines three novel ingredients that act synergistically to resolve melasma faster than bleaching agents. They are (a) Helix Aspersa Müller Glycoconjugates which dissolve the upper layer of dead cells with each application, while also activating and orchestrating the regenerative processes of the skin and have antioxidant and antiinflammatory properties, (b) Rumex occidentalis a plant extract which is capable of inhibiting the production of melanin by blocking the enzyme tyrosinase and (c) a human growth factor peptide, derived from the melanocyte-stimulating-hormone which blocks melanin synthesis.

BIO SKIN REJUVENATION activates skin renewal while it also dissolves excess pigmentation, blocks melanin synthesis and reduces the formation of unwanted pigmentation, allowing control over skin tone and brown spots.

The cream includes a human growth factor peptide, (nonapeptide 1) derived from the melanocyte-stimulating-hormone (MSH). It blocks melanin synthesis and reduces the formation of unwanted pigmentation, allowing control over skin tone and brown spots.

Melanocyte Stimulating Hormone (MSH) is a peptide hormone produced by the pituitary gland. When your body is exposed to sunlight MSH is produced to stimulate production and release of melanin (melanogenesis) by melanocytes in skin and hair.

The ingredient in the cream is a biomimetic peptide that takes the place of the natural ligand (alpha-MSH) on its specific receptor (MC1-R) and then blocks the melanin synthesis.

Peptides are made up of individual amino acids that are linked together like a pearl necklace. These are differentiated into oligopeptides (2-10 amino acids) and polypeptides (10-100 amino acids).

Biomimetic peptides are identical to the skin’s peptides. They act on the physiological mechanisms of the skin with a high specificity. Oligopeptides and polypeptides fulfill important tasks as hormones (peptide hormone) or as neurotransmitters or neuromodulators (neuropeptides).

Skin pigmentation and tanning are related to the amount and distribution of melanin in epidermal melanosomes. The epidermis cell population includes keratinocytes and the melanocytes that supply the keratinocytes with melanosomes, i.e., melanin containing pigment granules, via dendritic processes. Melanin is a dark pigment that is produced by the oxidation of tyrosine to dopa and dopaquinone by the enzyme tyrosinase, to produce compounds that polymerize to form melanin.

Ingredients that inhibit tyrosinase enzyme activity are derived from plants that are native to the northern Canadian prairie region. Rumex extracts are included which are capable of inhibiting the production of the enzyme tyrosinase, leading to clearer complexion and a reduction in skin pigmentation. They do this by limiting both melanin production (tan) and skin reddening (erythema). Visible signs of color reduction in age spots are observed after 3 weeks.

Our product regulates pigmentation tone for the total skin surface, lightening the complexion, and blocking the deleterious effects on the appearance caused by certain endocrine disorders. And it is a safe product for achieving such regulation of epidermal pigmentation tone. It helps with a number of localized hyperpigmentation disorders. These include pigmented spots such as freckles, solar lentigines (also called liver spots), acanthosis nigricans (a hypermelanotic disorder), cafe-au-lait spots, moles, and melasma (localized post-partum darkening of the skin).

BIO SKIN REJUVENATION reduces skin alterations by providing a complex biological compound containing a balanced mixture of NATURAL FACTORS THAT ACCELERATE SKIN RENEWAL & HELP TO RECOVER THE NORMAL PHYSIOLOGY OF THE SKIN.

1. Low molecular weight proteins that activate Fibroblast Growth Factor activity. Fibroblast proliferation is key for they are the stem cells in the basal membrane of the skin that give rise to new connective tissues: collagen and elastin fibers plus the glycosaminoglycans and proteoglycans that act as the glue that bind cells together and as fillers with a large capacity to withhold many times their weight in water and give skin strenght, elasticity and the capcity to withstand overstretching without breaking of skin fibers.

2. High molecular weight proteins that work as Oxygen carriers (copper-haemocyanin).

3. Copper peptides that induce the degradation of “extra-large” collagen aggregates found in scar tissues such as those in stretch marks, and promotes the synthesis of smaller more regular collagen as is normal skin.

4. Enzymes, both with Collagenase and Gelatinase activities that degrade damaged proteins and scar tissues.

5. Hyaluronic Acid, provides deep tissue hydration.

6. Glycoproteins/mucopolysaccharides that act as signaling molecules and enhance communication among and within cells, thus coordinating an orchestrated process that recognizes damaged and scar tissues, and activates the enzymes that “digest” or further degrade them into their amino-acid and other components, and uses those same components for the reconstruction of the extracellular matrix.

7. Trace elements (Copper, Zinc, Iron, Calcium), some acting as coenzymes, necessary for Cellular Renewal.

8. Low molecular weight antioxidant compounds with Antioxidant & Anti-Inflammatory effects.

The tissue-regenerating effect of BIOCUTIS serum is notable as it has been attested by studies done with a topical product including the biological ingredient at the Coaniquem Burn Center Foundation, a Non Profit Children’s Burn Hospital in Santiago, Chile. Also in clinical studies done in Spain, where a topical formulation with the ingredient was applied for the treatment of burns, blisters and damage to skin due to radiotherapy for cancer to 100 patients at the Hospital Ramon y Cajal in Madrid.

If you have scars of any type, stretch marks, surgery or accidental scars or burn marks on your face, hands, arms or anywhere in your body, and you want to restore your skin to its original beauty, then you’ll want to treat those scars with BIOSKINCARE or with BIO SKIN REJUVENATION.

What is the rich biological ingredient that yields effective results?

Read carefully, for what we are about to reveal can not only help you prevent and erase stretch marks and scars but may lead you to a lifetime of healthy skin. We guarantee you’ve never heard anything like it!

It is snail slime… YES, PRODUCED BY THE HUMBLE BROWN GARDEN SNAIL!

Our BIOCUTIS products embody this all-natural ingredient that has been known for its healing and restorative powers since antiquity, in ancient Greek times, and praised by Hippocrates himself, the father of modern medicine in the 4th Century, as a “sovereign remedy to treat pain related to burns, abscesses and other wounds”. (The Hippocratic Oath pertaining to the ethical practice of Doctors is authored by Hippocrates).

Since the 19th century there has been renewed interest in the pharmaceutical and medical use of snails, particularly for dermatological applications. But the most common purpose for raising escargots (snails) in modern times has been for food. That is, until people at a snail farm in Chile noticed that their handlers had exceptionally smooth hands, and any cuts or abrasions healed unusually quickly and without scarring.

This happens to be the ONLY substance in NATURE, created by a living creature to protect, moisturize, repair, and regenerate its own skin whenever wounded. It even regenerates its eyes with almost complete recovery of function when bitten by birds or large insects. It is even more amazing to find its skin is made with the same structural elements that human skin is made of: collagen, elastin, water holding molecules, etc.—

According to scientific breakdown the substance secreted by snails to regenerate their skin is a biological compound of complex glyco or sugar chain molecules bound to proteins, peptides, enzymes, co-enzymes and oligo-elements.

The snail we collect the secretion from is of the species Helix Aspersa Müller, also known as the humble brown garden snail. Using proprietary technology, no harm is inflicted upon the snails during the labor-extensive gathering process.

The serum produced by these snails has high Antioxidant Activity, which helps the snail to protect its body from oxygen radicals when it comes out of hibernation and from the effects of solar UVA radiation as it thrives exposed nude to the sun rays and the hazards of the environment, pretty much like we go around exposing our nude face. For human skin the glycoprotein secretion obtained from the gastropod Helix Aspersa Müller, also bears high Antioxidant Activity based on its ability to capture free radicals and is able to inhibit the production of free radicals in the skin. In addition, it bears superoxide dismutase as well as gluthation-S-transferase activities which are strong antioxidants.

The secretion also contains antimicrobial peptides and triggers the proliferation of antimicrobial peptides which protect the snail from being affected by attacks from opportunistic micro-organisms always ready to intrude when skin is injured. Now, isn’t that truly amazing! As a result, snails never suffer from skin infections – can you imagine?

Antimicrobials help to control acne and the other effects of the biological ingredient help to quickly repair lesions to the cells lining the hair follicles and to unblock cloged pores, so you can use the product to keep acne at bay while pregnant.

Also, the application of Biocutis on burned and damaged animal and human skin enhances Proliferation and Functional Capabilities of Fibroblasts, inducing synthesis of skin elements required for wound healing.

BIOCUTIS increases and properly regulates collagen synthesis, correct fibronectin deposition on the extracellular matrix and hyaluronic acid content. Both the facilitating and promoting activity of BIOCUTIS on the mechanisms of regulated cutaneous wound healing provide a rationale for its employment in the treatment of scars and stretch marks, and in reducing burn-induced skin alterations and treating the deleterious effects of radiotherapy for cancer.

We encourage you to read all about the ingredients, the particular molecules they are composed of, and their benefits for dark spots or discoloration and beauty care by following the links on the top menu.

BIOSKINREJUVENATION includes ingredients that inhibit tyrosinase enzyme activity and are derived from plants that are native to the northern Canadian prairie region. Rumex extract is included which is capable of inhibiting the production of the enzyme tyrosinase, leading to clearer complexion and a reduction in skin pigmentation. It does so by limiting both melanin production (tan) and skin reddening (erythema). Visible signs of color reduction in age spots and skin pigmentation disorders begin to be observed after 3 weeks.

Get Rid Of Melasma, Hyperpigmentation, Sun & Age Spots While Revitalizing and Protecting the Skin From The Effects of Free Radicals with BIO SKIN REJUVENATION

A deeply moisturizing natural skin care cream that replenishes the lipid barrier of the skin and triggers the repair of cells damaged by UV radiation and Free Radicals. Also gets rid of melasma, hyperpigmentation, brown, sun and age spots, actinic keratosis scales and all types of skin blemishes. The novel ingredients in BIOSKINCARE with an added natural substance that reduces melanin biosynthesis and a biomimetic peptide that inhibits the accumulation of melanin pigments.

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